Biomarkers of Pediatric Brain Tumors

نویسندگان

  • Mark D. Russell
  • Adam M. H. Young
  • Surya K. Karri
چکیده

UNLABELLED Background and Need for Novel Biomarkers: Brain tumors are the leading cause of death by solid tumors in children. Although improvements have been made in their radiological detection and treatment, our capacity to promptly diagnose pediatric brain tumors in their early stages remains limited. This contrasts several other cancers where serum biomarkers such as cancer antigen (CA) 19-9 and CA 125 facilitate early diagnosis and treatment. AIM The aim of this article is to review the latest literature and highlight biomarkers which may be of clinical use in the common types of primary pediatric brain tumor. METHODS A PubMed search was performed to identify studies reporting biomarkers in the bodily fluids of pediatric patients with brain tumors. Details regarding the sample type [serum, cerebrospinal fluid (CSF), or urine], biomarkers analyzed, methodology, tumor type, and statistical significance were recorded. RESULTS A total of 12 manuscripts reporting 19 biomarkers in 367 patients vs. 397 controls were identified in the literature. Of the 19 biomarkers identified, 12 were isolated from CSF, 2 from serum, 3 from urine, and 2 from multiple bodily fluids. All but one study reported statistically significant differences in biomarker expression between patient and control groups. CONCLUSION This review identifies a panel of novel biomarkers for pediatric brain tumors. It provides a platform for the further studies necessary to validate these biomarkers and, in addition, highlights several techniques through which new biomarkers can be discovered.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P154: Role of Exosomes as Novel Biomarkers in Diagnosis and Prognosis of Glioblastoma

Glioblastoma multiform(GBM) is the most prevalent primary brain tumor. Exosomes are extracellular vehicles for exchanging information between various cell types including cancer and normal cells. Exosomes are indicative of pathophysiological conditions of brain tumors that could be used in diagnosis and prognosis of GBM. In tumors, exosomes could carry various molecules like several miRNAs and ...

متن کامل

Epidemiological features of Central Nervous System tumors at MAHAK Pediatric Cancer Treatment and Research Center

Background: In this study, we examined the epidemiologic characteristics of childhood brain tumors in patients referred to MAHAK Pediatric Cancer Treatment and Research Center (one of the main national referral centers for childhood malignancies in Iran) for treatment. Materials and Methods: This cohort (simple sampling) study consisted of 198 children less than 15 year old with CNS tumor ref...

متن کامل

EMT related lncrnas’ as novel biomarkers in glioblastoma: a review article

Glioma is the most common type of brain tumor and according to the 2016 WHO classification, based on invasion level, it is divided into four categories. The most severe and invasive type is grade IV glioma or glioblastoma (GBM), which has a very poor prognosis and a survival rate of only 15 months. However, the molecular pathway of invasion in malignant glioma tumors has not yet been clearly el...

متن کامل

Computerized Addenbrooke’s Cognitive Examination for Neurocognitive Monitoring of Children with Benign and Malignant Brain Cerebellar Tumor

Background: Brain tumors in the cerebellum site, especially in the cranial nuclei, are most commonly associated with cognitive impairment in children, but the differences in dimensions of cognitive impairments in pediatric benign and malignant tumors are rarely studied. Meanwhile, cognitive impairments in this area are required to be widely studied. This study aimed at using Computerized Addenb...

متن کامل

بررسی عوامل خطر احتمالی تومورهای مغزی در کودکان و نوجوانان

Introduction: Based on the findings of studies, brain tumors result in the decline of pediatric performance and quality of life. Therefore, this study aims at investigating different epidemiologic, demographic and clinical factors in children and adolescents with brain tumors in Arak, Iran. Methods: This case–control study was conducted on 50 children with brain tumor (with the age range of 1....

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 1  شماره 

صفحات  -

تاریخ انتشار 2013